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ZWJ-12高压计量
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你可能喜欢Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:FunctioniEnhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).Names & TaxonomyiProtein namesiRecommended name:Kielin/chordin-like proteinAlternative name(s):Cysteine-rich BMP regulator 2Cysteine-rich motor neuron 2 proteinShort name: CRIM-2Kielin/chordin-like protein 1Short name: KCP-1Gene namesiName:Synonyms:CRIM2, KCP1OrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi Componenti: Unplaced Organism-specific databases
HGNCi KCP. Subcellular locationi GO - Cellular componentiKeywords - Cellular componentiPathology & BiotechiOrganism-specific databases
PharmGKBi Polymorphism and mutation databases
DMDMi PTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsSignal peptidei26Chaini1477Kielin/chordin-like proteinPRO_Amino acid modificationsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsGlycosylationi1N-linked (GlcNAc...)Disulfide bondiKeywords - PTMi, Proteomic databases
PRIDEi PTM databases
PhosphoSitei ExpressioniGene expression databases
CleanExi InteractioniSubunit structureiInteracts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).Structurei3D structure databases
ProteinModelPortali
SMRi Positions
MobiDBiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsDomaini58VWFC 1Domaini61VWFC 2Domaini59VWFC 3Domaini60VWFC 4Domaini60VWFC 5Domaini60VWFC 6Domaini59VWFC 7Domaini60VWFC 8Domaini59VWFC 9Domaini58VWFC 10Domaini60VWFC 11Domaini63VWFC 12Domaini60VWFC 13Domaini59VWFC 14Domaini69VWFC 15Domaini64VWFC 16Domaini61VWFC 17Domaini213VWFDDomaini61TILCoiled coilFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsCoiled coili33Sequence similaritiesiContains 1 .Contains 17 s.Contains 1 .Keywords - Domaini, , Phylogenomic databases
InParanoidi
PhylomeDBi Family and domain databases
InterProi Kcp.
Unchr_dom_Cys-rich.
VWF_type-D.
PANTHERi PTHR11339:SF280. 2 hits.
Pfami VWC. 8 hits.
VWD. 1 hit.
SMARTi C8. 1 hit.
VWC. 16 hits.
VWD. 1 hit.
SUPFAMi SSF57567. 1 hit.
PROSITEi VWFC_1. 12 hits.
VWFC_2. 15 hits.
VWFD. 1 hit.
[]Sequences (2)iSequence statusi: Complete.Sequence processingi: The displayed sequence is further processed into a mature form.This entry describes 2 isoformsi produced by alternative splicing.
(identifier: Q6ZWJ8-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ
100EQWHPLREWL GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG
150RAWPEGARWE PDACTACVCQ DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET
200FSPDACTTCR CLTGAVQCQG PSCSELNCLE SCTPPGECCP ICCTEGGSHW
250EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP LPGTCCPVCD
300GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP
350GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV
400TPCALPASGR QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA
450VLCPPAPCQH PTQPPGACCP SCDSCTYHSQ VYANGQNFTD ADSPCHACHC
500QDGTVTCSLV DCPPTTCARP QSGPGQCCPR CPDCILEEEV FVDGESFSHP
550RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS GCAFGGKEYP
600SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA
650PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP
700RQGPCCPSCD GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA
750PALCPFPARG DCCPDCDGCE YLGESYLSNQ EFPDPREPCN LCTCLGGFVT
800CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY HGVTTASGET LPDPLDPTCS
850LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ GREHQDGEEF
900EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG
950EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ
1000CSDCEHEGRK YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV
1050GCPPSQLLPP GPQHCCPTCA EALSNCSEGL LGSELAPPDP CYTCQCQDLT
1100WLCIHQACPE LSCPLSERHT PPGSCCPVCR APTQSCVHQG REVASGERWT
1150VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC PRCLPRPASC
1200MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA
1250WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL
1300HAQPGLQVLW DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL
1350LPSEAAFGNS WQVSEGLWPG RPCSAGREVD PCRAAGYRAR REANARCGVL
1400KSSPFSRCHA VVPPEPFFAA CVYDLCACGP GSSADACLCD ALEAYASHCR
1450QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ HIPLGELAAH
1500CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ ETP
1,503159,938December 16, 2008 - v2Checksum:iB6E0BBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q6ZWJ8-2)
[]The sequence of this isoform differs from the canonical sequence as follows:&&&&&: Missing.&&&&&: SEGLWPGRPC...AYASHCRQAG&&&QEGRGYPPGL...LKASCDGSRL&&&&&: Missing.Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.&29431,744Checksum:iC0925BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterNatural variantFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsNatural varianti1.Corresponds to variant rs7787221 [
].VAR_038783Natural varianti1.Corresponds to variant rs7782976 [
].VAR_059625Natural varianti1.Corresponds to variant rs3734971 [
].VAR_059626Natural varianti1.Corresponds to variant rs7786641 [
].VAR_059627Alternative sequenceFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsAlternative sequencei1109Missing
in isoform . "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). VSP_036045Alternative sequencei90SEGLW&CRQAG & QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform . "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). VSP_036046Alternative sequencei100Missing
in isoform . "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). VSP_036047Sequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: .
UniGeneiGenome annotation databases
UCSCi human.
[]Keywords - Coding sequence diversityi, Cross-referencesiSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: .
UniGenei3D structure databases
ProteinModelPortali
SMRi Positions
MobiDBiPTM databases
PhosphoSitei Polymorphism and mutation databases
DMDMi Proteomic databases
PRIDEi Protocols and materials databases
Structural Biology KnowledgebaseGenome annotation databases
UCSCi human.
[]Organism-specific databases
GeneCardsi
HGNCi KCP.
MIMi gene.
GenAtlasiPhylogenomic databases
InParanoidi
PhylomeDBi Miscellaneous databases
ChiTaRSi human.
GenomeRNAii
SOURCEiGene expression databases
CleanExi Family and domain databases
InterProi Kcp.
Unchr_dom_Cys-rich.
VWF_type-D.
PANTHERi PTHR11339:SF280. 2 hits.
Pfami VWC. 8 hits.
VWD. 1 hit.
SMARTi C8. 1 hit.
VWC. 16 hits.
VWD. 1 hit.
SUPFAMi SSF57567. 1 hit.
PROSITEi VWFC_1. 12 hits.
VWFC_2. 15 hits.
VWFD. 1 hit.
ProtoNetiPublicationsi"Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: . , , , , , , , , , , , , , , , , ,
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. MiscellaneousiKeywords - Technical termi, Documents
Human chromosome 7: entries, gene names and cross-references to MIM
List of human entries with polymorphisms or disease mutations
Index of human polymorphisms and disease mutations
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Index of protein domains and families
External DataSimilar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.城市治安动态监控系统宣传资料(zwj修改)_图文_百度文库
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