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药为动力学模型-一室模型
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&&&&RESULTS The plasma concentration-time curves of olmesartan were fitted to a one-compartment model after a oral olmesartan medoxomil tablet in single dose(20, 40, 80 mg). The main pharmacokinetic parameters of olmesartan were as follows: Tmax were (2.7±1.4), (2.6±0.8) and (2.8±0.8)
&&&&结果奥美沙坦的体内经时过程符合有滞后时间的一室模型,低、中、高三个剂量组单剂量口服给药后血浆中奥美沙坦的Tmax分别为(2.7±1.4),(2.6±0.8)和(2.8±0.8)h;
&&&&The pharmacokinetics of [~3H]-dihydroetorphine in mice was studied with different doses(1,2,4,8, 16μg/kg). The time curves of blood drug concentration were fitted to one-compartment model by employing IMIPPO program.
&&&&小鼠皮下注射不同剂量(1.0、2.0、4.0、8.0、16μg/kg)[~3H]-双氢M99的药-时曲线符合一室模型。
&&&&Propafenone pharmacokinetics was studied after single oral administration of 600 mg in 10 health volunteers. Serum concentration-timedata were fit to a one-compartment model for 8 but 2 volunteers, whosedata required fitting to a two-compartment model. The mean eliminationt1/2 was 3.03 ±1. 38h, tmax 3.02±0.87h, AUC μg.
&&&&10名健康志愿者单剂口服心律平600mg后药时曲线8名为一室模型,2名为二室模型,平均消除半衰期(t1/2)3.03±1.38h,达峰时间(t max)3.02±0.87h,曲线下面积(AUC)μg·h/l。
&&&&The drug concentration in plasma and urine were assayed byHPLC method. The plasma concentration-time curve of fleroxacin administeredorally could be best described by an open one-compartment model. Their mainmean parameters were as follows: AUC: 82. 30±14. 30, 81. 13±8. 45 and 83. 92±14. 2 h·mg/L;
&&&&血、尿药浓度用HPLC检测．结果表明：体内过程符合一室模型，主要药代动力学参数分别为：AUC：82.30±14．30、81．13±8．45与83．92±14.27h·mg／L；
&&&&One-compartment model was used. RESULTS: Pharmacokinetic pa-rameters were:Ke: (0.015 9±0.006 3) l/min,T_(1/2): (49. 57 ±19. 70)mim:V: (11 637. 03±9 730.24)
&&&&结果:血浆浓度-时间曲线以一室模型拟合,Ke:(0.015±0.06 3)1/min,T_1/2:(49.57±19.70) 表观分布客积V:(11 637.03±9 730.24)
&&&&For pharmacokinetics, the compater simulated curve demonstrates that the result confrom to the one compartment model. The biological half-life T1/2 is 55.9 minutes, and K is 0.0124 minute.
&&&&对于药物代谢动力学,计算机模似结果为一室模型,其中生物半衰期T_(1/2)为55.9分钟,K值为0.0124分钟。
&&&&The concentration time curve(cephalexin 0.5g PO) was shown as one compartment model.
&&&&浓度时间曲线(头孢氨苄0.5g,PO)显示为一室模型。
&&&&The results showed that the drug disposition reveled one compartment model,the elimination half-life(T1/2)was 11.60+4.16h. It was increase obivously compared with T1/2 of normal elderly men from published reports.
&&&&结果表明患者体内药物处呈一室模型，消除半衰期为11．60±4．16h，比文献［1］报道的健康老人的消除半衰期（T1／2）有明显延长。
&&&&Serum concentration of Ciprofloxacin was determined by microbiological assay in 6 elderly patients with chronic obstructive disease of lung after oral administration of the drug. The drug in vivo was fitted to one compartment model. The main pharmacokinetic parameters of Ciprofloxacin are as follow: T1/2 = 5.14 ± 1.13
&&&&应用微生物法测定6名老年慢性阻塞性肺病患者多次po环丙沙星片后的血清药物浓度,药物体内过程符合一室模型,其主要药动学参数分别为:T_(1/2)=5.14±1.13h,Vc/F=6.6±4.2L╱kg,(C∞)max=2.73±1.02μg/
&&&&erum concentration of ofloxacin was determined by microbiological assay in 6 healthy volunteers after oral ad-ministration of multiple dose. The drug in vivo fitted in with one compartment model. The main pharmacokineticparameters of ofloxacin were as follow: T1/2 = 3. 74 ± 0. 46h;
&&&&应用微生物法测定6名健康志愿者多次口服氧氟沙星片达稳态后的血清药物浓度，药物体内过程符合一室模型，其主要药物动力学参数分别为：T＿（1／2）＝3．74±0．46h；
&&&&The results showed that the pharmacokinetic model of BLA in healthy volunteers after injection conformed to single compartment model, and values of Tmax, Cmax, AUC0-∞, k and t1/2 were 0.9h, 1.134ng/ml, 6.014ng.
&&&&试验结果表明，草乌甲素注射剂在健康志愿者体内的药动学模型近似一室模型，药动学参数：Tmax=0.9h、Cmax=1.134ng/ml、AUC0-∞=6.014ng.
&&&&Pharmacokinetic parameters were ob-tained using 3P87 program,and were calculated on the basis of an open single compartment model.
&&&&药一时数据用3P87程序拟合,按一室模型计算药物动力学参数.
&&&&METHODS:According to the crossover design,each volunteer was orally given cefaclor granules,and the plasma concentrations were determined by RP-HPLC. Phar-macokinetic parameters were obtained using 3P87 program,and were calculated on the basis of open single compartment model.
&&&&方法:同体交叉试验后,用RP-HPLC法测定血浆中头孢克洛浓度,药-时数据用3P87程序拟合,按一室模型计算药物动力学参数.
&&&&Methods
According to the crossover design, each volunteer in two groups was orally given a single dose (
) of domestic penicillin V dispersion tablet or imported penicillinV tablet alternately and the plasma concentrations were determined by RP
HPLC. The pharmacokinetic parameters were obtained by using ATPK program and calculated on the basis of open single compartment model.
&&&&方法　 12名健康志愿者双交叉口服单剂量国产青霉素V钾分散片和进口片剂 0 .75 g,用RP HPLC法测定人血浆中青霉素V浓度 ,药
时数据用ATPK程序拟合 ,按一室模型计算药物动力学参数。
&&&&The t(1/2) of SM in normal saline was 4.80 min, and in other biosamples were 4-7 min. The time course of SM concentration in blood of piglet following iv SM 10 mg/kg fitted the three-compartment open model. Following a subcutaneous injection of SM, thetoxicokinetics of SM in piglet appeared to fit a first-order absorption one-compartmen open model.
&&&&SM在生理盐水中的t_(1/2)为4.80min,在其它生物样品中为4-7min,小猪iv SM符合三室开放模型,sc SM呈一级吸收一室模型,pc SM200mg/kg,4h内均未从血中检出SM。
&&&&The pharmacokinetics of SC_(1001)-Sodiumand SC_(1001)-Aminum in the human bodywas studied. After 200mg SC_(1001)-Sodiumor SC_(1001)-Aminum by oral administration,plasma concentration-time data were fittedto curves by means of the nonlinear least-square method, employing the program weourselves compiled. With F-test, comparingγ_1~2 -value and AIC-value, the linear onecompartment open model was available.
&&&&健康人口服SC1001钠盐或SC1001胺盐200mg后,血药时间数据用自编程序进行非线性最小二乘法曲线拟合,经F检验、γ_1~2和AIC值比较,符合线性一室模型。
&&&&One-thirdof the volunteers absorbed slowly and the drug level-time curves wereone-compartment model, The maximum level was 8. 89mg/l at 3 hours afteradministration.
&&&&2例慢吸收的药—时曲线为一室模型,峰时间为3h峰浓度也较低,为8.89mg/l。
&&&&The charac-teristics were fitted to one compartment open model. The parameters wereas following: K=0. 182 ±0. 095, t_(1/ 2) = 4. 66± 1. 97, V_d= 6. 13 ±2. 4 l/kg. Beforeiv infusion, the C_P of Mg was among the normal range and was used asa baseline.
&&&&首先测定了MgSO_4在妊娠高血压症病人的药代动力学特征,其血药浓度的时间过程符合一室模型,药代动力学参数为:K=0.182±0.095h~(-1),t1/2=3.66±1.97h,V_d=6.13±2.4 l/kg。
&&&&After oral administration, the curve of 1 concentration vs time was fit for onecompartment model,t1/2 was 13.837±2.499h,and AUC was 19.305±5.702μgh/ml. After iv administration,the curve of 1 concentration vs time was fit for twocompartment model,t1/2 was 16.161±4. 604h,and AUC was 20.852±5.178μgh/ml.
&&&&口服和静注后药时曲线分别符合有吸收的一室模型和无吸收的二室模型，消除半衰期为13．837±2．499及16．161±4．604h，药时曲线下面积为19．305±5．702及20．852±5．178μgh／ml。
查询“一室模型”译词为用户自定义的双语例句&&&&我想查看译文中含有：的双语例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&& The present paper reports the pharmacokinetic studies ofaminophylline in 6 healthy adults (3 male and 3 female). A high-perfor-mance liquid chromatographic method for measurement of plasma theophyllinewas described. The chromatography system included a C18/MCH-5 reversecolum and methanol-double distilled water (25/75 by vol)as the mobile phase.It was a simple, accurate and sensitive assay method, required only 30μl plasma, with interassay coefficients of variation of 1.3-5.7%. The plasmaconcentration of theophylline... The present paper reports the pharmacokinetic studies ofaminophylline in 6 healthy adults (3 male and 3 female). A high-perfor-mance liquid chromatographic method for measurement of plasma theophyllinewas described. The chromatography system included a C18/MCH-5 reversecolum and methanol-double distilled water (25/75 by vol)as the mobile phase.It was a simple, accurate and sensitive assay method, required only 30μl plasma, with interassay coefficients of variation of 1.3-5.7%. The plasmaconcentration of theophylline were measured at different times after a sin-gle oral 300mg dose of aminophylline and intravenous 0.25g dose of amino-phylline. Pharmacokinetic parameters were calculated by one-compartmentand two-compartment kinetic analysis for oral and intravenous administrationrespectively. The results showed that the rate of absorption, distributionand climination were rapid, the drug distribution in vivo was wide with anappreciable distribution in the intracellular spacc. There was large interin-dividual variation in the pharmacokinetics of aminophylline. The rates ofabsorption and elimination of aminophylline in male were faster than thatin female. On the bases of the data obtained, the lower plasma levels oftheophylline were obtained when oral dosage of aminophylline was 0.1g,every 8 hours. Therefore, it was proposed that the oral dosage of amino-phylline should be increased appropriately, if the gastrointestinal tract ofpatient was tolerant.本文阐述了氨茶碱血药浓度测定的一种简便、灵敏、精确的高效液相色谱测定法,以及六名正常成人口服0.3g与静脉注射0.25g氨茶碱的药代动力学性质。分别按线性一室模型与二室模型计算出有关参数。氨茶碱的吸收速率常数=0.983～2.260h~(-1)、药峰时间=1.43～2.80h、消除速率常数=0.076～0.102h~(-1)、半衰期=6.79～9.15h、总清除率=0.027～0.048L·h~(-1)·kg~(-1),说明氨茶碱口服吸收迅速良好,从血浆中的清除也比较快。氨茶碱的表观分布容积=0.346～0.472L/kg,提示该药分布较广泛,能一定程度地到达细胞内间隙。氨茶碱药动学有明显的个体差异,在药物的吸收与消除速率方面,男性比女性均快。根据药动学参数估算临床氨茶碱口服常规用法(0.1g,每8h一次)时的血药浓度可能偏低。 Pharmacokinetics of tiapri- de in 3 males together with its relative bioavaiiability in 6 males were studied. After a single dose either tiapride 200 mg per person given intravenously or 150 mg taken by mouth, drug concentrations in plasma and urine were determined by high-performance liquid chromatogra-phy. pharmacokinetic parameters were calculated according to linear one-corn-partment and two-compartment models respectively. Results revealed that the half-lifes during the disposition phase ranged from 2.52... Pharmacokinetics of tiapri- de in 3 males together with its relative bioavaiiability in 6 males were studied. After a single dose either tiapride 200 mg per person given intravenously or 150 mg taken by mouth, drug concentrations in plasma and urine were determined by high-performance liquid chromatogra-phy. pharmacokinetic parameters were calculated according to linear one-corn-partment and two-compartment models respectively. Results revealed that the half-lifes during the disposition phase ranged from 2.52 to 3.17 h with mean 2.83 the absorpt'on rate constants wore 0.634 to 2.48 h-1; the climination rate constants were 0.22 to 0.28 h-1 the本文阐述了用高效液相色谱法测定静脉推注泰必利与正常人口服泰必利水溶液的药物动力学结果。口服该药的血浓度及尿浓度数据按线性一室模型处理;静脉推注数据按线性二室模型处理。该药国产原料相对于法国原料的生物利用度为96％,它在尿中以原形排泄的百分率为81％,国产泰必利与法国产品的药物动力学参数基本一致。 The pharmacokinetics of quinidine was studied in 10 hospitalized patientswith chronic atrial fibrillation (without heart failure). A 200mg quinidinesulfate (equivalent to 165. 5mg of quinidine base) was given orally to eachpatient in a sugar coated tablet. The blood quinidine concentration was deter-mined by photofluorometric method. The curves of serum concentration-timeshowed that a one-compartment open model could be used in all subjects withan equation Ct=1. 75 (e~(-0.0905t)-e~(-2.1818t), and with following... The pharmacokinetics of quinidine was studied in 10 hospitalized patientswith chronic atrial fibrillation (without heart failure). A 200mg quinidinesulfate (equivalent to 165. 5mg of quinidine base) was given orally to eachpatient in a sugar coated tablet. The blood quinidine concentration was deter-mined by photofluorometric method. The curves of serum concentration-timeshowed that a one-compartment open model could be used in all subjects withan equation Ct=1. 75 (e~(-0.0905t)-e~(-2.1818t), and with following pharmacoki-netic parameters (mean value): t_(1/2k)=7. 79±1. 16 (hr); t_(1/2ka)=0. 52±0. 41(hr);Tm=2.03±1.00 (hr); Cm=1.51±0.50 (μg/ml); V=1. 73±0. 37 (l/kg); AUC=19. 42±5. 72 (μg. hr/ml); CL=2. 57±0. 81 (ml/min/kg).本文采用荧光光度法测定血药浓度,对10例慢性房颤病人(均无心衰)口服奎尼丁200mg(相当于奎尼丁碱165_e5mg)的药代动力学进行了研究。药时曲线表明所有病例均为开放性一室模型,药时方程为Ct=1.75(e~(-0.0905t)-e~(-2.1818t),药代动力学参数如下:t_(1/2k)=7.79±1.16(hr);t_(1/2ka)=0.52±0.41(hr);Tm=2.03±1.00(hr);Cm=1.51±0.50(μg/ml);V=1.73±0.37(l/kg);AUC=19.42±5.72(μg·hr/ml);CL=2.57±0.81(ml/min/kg)。&nbsp&&&&&相关查询
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