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目录号：S1516
别名： HPMPC
Molecular Weight(MW): 279.19
Cidofovir通过选择性抑制病毒DNA的合成而抑制病毒复制。
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客户购买Selleck的此次产品后发表的文献2篇：
客户使用该产品的2个实验数据：
The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 &M) was used as a positive control. CDV:Cidofovir.
Viruses 68-2287. .
Cidofovir purchased from Selleck.
Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.
Int J Oncol, ):1519-30. .
Cidofovir purchased from Selleck.
产品安全说明书
DNA/RNA Synthesis抑制剂选择性比较
Cidofovir通过选择性抑制病毒DNA的合成而抑制病毒复制。
Cidofovir处理培养的细胞，抑制人类巨细胞病毒（HCMV）感染。Cidofovir抑制巨细胞病毒（CMV）蚀斑形成，即使是感染后48小时后加入到细胞中，作用于Davis和AD-169株时IC50分别为0.9 μg/mL和1.6 μg/mL。 Cidofovir也抑制单纯疱疹病毒感染。此外，Cidofovir作用于猴肾细胞，抑制HSV-1诱导的细胞融合，也抑制HSV-1特异性蛋白的表达和病毒DNA的合成。
Cell Lines
Assay Type
Concentration
Incubation Time
Formulation
Activity Description
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MRC-5 cells
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NHDF cells
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bone marrow cells
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MRC5 cells
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UC1B cells
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african green monkey Vero cells
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HeLaS3 cells
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HSB2 cells
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A549 cells
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MoK4NlE{PzZ2Mkm=
Cidofovir 每天按5 mg/kg剂量皮下注射给药受感染的豚鼠，持续给药5天，显著降低血，脾，肺，和唾液腺中病毒传染力。Cidofovir处理受感染的动物，显著降低淋巴细胞增多和脾脏的平均组织指数。 Cidofovir作用于皮内感染与HSV-1或HSV-2的无毛小鼠，抑制所有临床表现（皮肤损伤，后腿瘫痪，和死亡）。Cidofovir最显着的特点是感染后到直至第4天才单独给药，也显著抗HSV-1或HSV-2感染。 Cidofovir作用于皮下移植小鼠黑色素瘤B16细胞的C57B16/J小鼠，抑制产生的高度侵袭性的黑色素瘤的生长。
推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)
溶解度 (25°C)
(42.98 mM)
* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。
C8H14N3O6P
3 years -20&C powder
摩尔浓度计算器
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量
摩尔浓度计算公式
*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。
稀释计算器
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出
在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.
连续稀释计算器方程
分子量计算器
通过输入化合物的化学式来计算其分子量：
总分子量：g/mol
注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2
摩尔浓度计算器
临床试验信息
(data from , updated on )
NCT Number
Recruitment
Conditions
Sponsor/Collaborators
Start Date
Not yet recruiting
University of Minnesota - Clinical and Translational Science Institute
Recruiting
Recurrent Respiratory Papillomatosis
Centro de Investigación en. Enfermedades Infecciosas, Mexico
December 2014
Blood And Marrow Transplantation
M.D. Anderson Cancer Center|Gilead Sciences
September 2013
Fundacion SEIMC-GESIDA
September 2013
High Grade Cervical Epithelial Neoplasia (CIN2+)
Brugmann University Hospital
February 2013
Cystitis|Bladder Diseases
M.D. Anderson Cancer Center|Gilead Sciences
September 2012
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