Annales de Dermatologie et de V?(C)n?(C)r?(C)ologie
[New toxicity of fotemustine: diffuse interstitial lung disease].
M Bertrand, L Wémeau-Stervinou, S Gauthier, M Auffret, L Mortier
Index: Ann. Dermatol. Venereol.
139(4) , 277-81, (2012)
Full Text:
Fotemustine is an alkylating cytostatic drug belonging to the nitrosourea family and is used in particular in the treatment of disseminated malignant melanoma. Herein, we report a case of interstitial lung disease associated with fotemustine.An 81-year-old man treated with fotemustine for metastatic melanoma presented acute interstitial lung disease 20 days after a fourth course of fotemustine monotherapy. The condition regressed spontaneously, with the patient returning to the clinical, radiological and blood gas status that had preceded fotemustine treatment. After other potential aetiologies had been ruled out, acute fotemustine-induced lung toxicity was considered and this treatment was definitively withdrawn.Other cytostatic agents belonging to the nitrosourea family can cause similar pictures, with a number of cases of interstitial lung disease thus being ascribed to fotemustine and dacarbazine. To our knowledge, this is the first case of interstitial lung disease induced by fotemustine monotherapy. This diagnosis should be considered where respiratory signs appear in melanoma patients undergoing fotemustine treatment.Copyright (C) 2012 Elsevier Masson SAS. All rights reserved.
Related Compounds
Diethyl (1-(3-(2-c...
Related Articles:
Multiple bone metastases from glioblastoma multiforme without local brain relapse: a case report and review of the literature.
99(5) , e237-40, (2013)]
Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma.
[J. Transl. Med.
11 , 38, (2013)]
Good clinical activity and favorable toxicity profile of once weekly bortezomib, fotemustine, and dexamethasone (B-MuD) for the treatment of relapsed multiple myeloma.
[Am. J. Hematol.
88(2) , 102-6, (2013)]
High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.
[J. Transl. Med.
8 , 115, (2010)]
Fotemustine in the treatment of brain primary tumors and metastases.
[Cancer Invest.
12(4) , 414-20, (1994)]
&2018 ChemSrc All Rights Reserved.Journal of experimental & clinical cancer research : CR
Focus on Fotemustine.
A De Rossi, L Rossi, A Laudisi, V Sini, L Toppo, F Marchesi, G Tortorelli, M Leti, M Turriziani, A Aquino, E Bonmassar, L De Vecchis, F Torino
Index: J. Exp. Clin. Cancer Res
25(4) , 461-8, (2006)
Full Text:
Fotemustine is a cytotoxic alkylating agent, belonging to the group of nitrosourea family. Its mechanism of action is similar to that of other nitrosoureas, characterized by a mono-functional/bi-functional alkylating activity. Worth of consideration is the finding that the presence of high levels of the DNA repair enzyme O6-methylguanine-DNA-methyltransferase (MGMT) in cancer cells confers drug resistance. In different clinical trials Fotemustine showed a remarkable antitumor activity as single agent, and in association with other antineoplastic compounds or treatment modalities. Moreover, its toxicity is generally considered acceptable. The drug has been employed in the treatment of metastatic melanoma, and, on the basis of its pharmacokinetic properties, in brain tumors, either primitive or metastatic. Moreover, Fotemustine shows pharmacodynamic properties similar to those of mono-functional alkylating compounds (e.g. DNA methylating drugs, such as Temozolomide), that have been recently considered for the management of acute refractory leukaemia. Therefore, it is reasonable to assume that this agent could be a good candidate to play a potential role in haematological malignancies.
Related Compounds
Diethyl (1-(3-(2-c...
Related Articles:
Multiple bone metastases from glioblastoma multiforme without local brain relapse: a case report and review of the literature.
99(5) , e237-40, (2013)]
Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma.
[J. Transl. Med.
11 , 38, (2013)]
Good clinical activity and favorable toxicity profile of once weekly bortezomib, fotemustine, and dexamethasone (B-MuD) for the treatment of relapsed multiple myeloma.
[Am. J. Hematol.
88(2) , 102-6, (2013)]
High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.
[J. Transl. Med.
8 , 115, (2010)]
Fotemustine in the treatment of brain primary tumors and metastases.
[Cancer Invest.
12(4) , 414-20, (1994)]
&2018 ChemSrc All Rights Reserved.PRODUCT LIST
The briquetting machine, with other names of briquetting press machine, briquettes machine, briquette machine and briquette press machine, is mainly used to process tailing disposals and suppress powder materials that are hard to take shape.
The quick lime is a kind of powder material that is hard to be briquetted, and without using any adhesive, it’s difficult to guarantee the one time briquetting process according to the traditional experience.
The desulfurization gypsum briquette machine with features of both high yield and high briquetting rate about 90% can compress desulfurization gypsum powder into one-time ball products with strong hardness without any help of adhesives.
Coal briquette machine or coal briquetting machine is also called coal ash briquette machines, coal briquetting plant or coal briquette plant whose molding process can be classified into cold briquetting and hot briquetting,
Charcoal briquette machine is mainly used to press various powder and scrap materials such as charcoal dust, the bamboo carbon powder, breeze, hookah carbon, graphite powder,
The ore powder briquetting machine, also called the mineral powder briquette machine, is mainly used to process raw materials like iron powder, ore powder, iron oxide, steel slag, refractory matter etc.
The dry powder briquetting machine is widely used to make balls from all kinds of powder materials like lime powder, cryolite, alumina, chemical fertilizer,
The fluorite power or the fluorite ore is mainly used as the steel making dissolving agent. As the government starts to be strict about the management of the mine exploitation, it’s more and more difficult to exploit the scarce fluorite ore.
While the wet powder briquetting machine owns lower indexes and higher efficiency. So, once you need to briquette materials, you may prefer the wet powder briquetting machine to the dry one.
Fote hydraulic briquette machine can be used to press various mineral powder, metal powder, pulverized coal, coke powder and other materials into balls.
The magnesium metal briquetting machine is mainly used to make balls from the ferrous metal and non-ferrous metal powders by throwing them directly into the smelting furnace which increases the additional value.
The strong hydraulic briquetting machine or the hydraulic pressure briquette machine is mainly used to press powder materials that are hard to be formed.
LATEST NEWS
Charcoal briquette machine is the symbol of china to explore the charcoal briquettes.
Along with the gradual development of manufacturing level and market competition, we more and more focus on the improvement of management level.
LEAVE MESSAGEFote下载_Fote安卓版apk下载-优亿市场
请输入6-16位密码
适用：2.2以上
完全的网络访问权限
查看网络连接
更新时间：
扫描二维码安装
是目前最安全可靠的安卓软件下载平台，我们为用户提供高质量的《Fote》下载服务。更多精彩内容请关注我们（）！
The easy way to keep track of your daily expenses.Just by making financial notes (Fote).To add a transaction, simple click on the &+& icon.
下载数：200次
下载数：200次
下载数：200次
下载数：200次
下载数：200次
下载数：200次
下载数：200次
下载数：4万次
下载数：700次
无法安装或启动
不是最新版本
您的举报信息将会同步到工信部12321举报平台
点击下面的按钮下载4.7.4版本
获取验证码
恭喜你，密码重置成功
用户客服QQ：
开发者反馈QQ：
客服邮箱：
举报电话：
商务合作QQ：
资讯投稿：
(C) www.eoemarket.com 版权所有 北京浩游网讯科技有限公司
感谢使用优亿市场，恳请您提出宝贵的建议，被采纳的建议均可获得30元话费充值卡。
请输入您的意见建议，万分感谢！
联系方式（可选）
加群抢红包！}