C.Cg-Tg(DO11.10)10Dlo/J
Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment. These mice may be useful for studies of T cell selection and death in immune responses and in the generation of tolerance, as well as for studying the mechanisms of apoptosis.
Donating InvestigatorDr. Kenneth Murphy, Washington Univ School of Medicine
Genetic overview
Genetic Background
Generation
Allele Type
Transgenic
(Inserted expressed sequence)
Research Applications
Immunology, Inflammation and Autoimmunity ResearchResearch Tools
Base Price
Starting at:
$136.34 Domestic price for female 3-week
Detailed Description
Mice carrying the MHC class II restricted rearranged T cell receptor transgene, Tg(DO11.10)10Dlo, react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes within 20 hours of treatment indicates that apoptosis in important in the development of antigen-induced tolerance. Use of this rearranged T cell receptor transgene requires H2d background.
Development
Constructs, about 45 to 50 kilobases, made from full genomic TCR rearranged genes from the DO11.10 hybridoma of Kappler and Marrack were co-microinjected into (B6C3F1) female X BALB male embryos. Founder mice were bred back to BALB/c.
The Tg(DO11.10)10Dlo transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor.
Expression Data
Expressed Gene
Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene
Tcrb, T cell receptor beta chain, mouse, laboratorySite of Expression&
Control Suggestions
Additional Information
Selected ReferencesMurphy KM; Heimberger AB; Loh DY. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250(-3.
Tg(DO11.10)10Dlo
Allele Symbol:
Allele Name
transgene insertion 10, Dennis Y Loh
Allele Type
Transgenic (Inserted expressed sequence)
Allele Synonym(s)
CO11.10 TCR- D10; DO-11.10; DO-Tg; DO.10 Tg; DO.11; DO.11.10 TCR; DO11; DO11 TCR; DO11.10; DO11.10 TCR; DO11.10 TCR Tg; DO11.10 alphabeta-TCR; DO11.10TCR Do11.10 alphabeta TCR; Do11.10 alphabetaTCR; OVA-TCRtg; Tg(DO11.10)Tcra/T TgN(DO11.10)10D TgN(DO11.10)10Loh
Gene Symbol and Name
, transgene insertion 10, Dennis Y Loh
Gene Synonym(s)
CO11.10 TCR- DO-11.10; DO-Tg; DO.10 Tg; DO.11; DO.11.10 TCR; DO11; DO11 TCR; DO11.10; DO11.10 TCR; DO11.10 TCR Tg; DO11.10 alphabeta-TCR; DO11.10TCR Do11.10 alphabeta TCR; Do11.10 alphabetaTCR; OVA-TCRtg; Tg(DO11.10)Tcra/T TgN(DO11.10)10D TgN(DO11.10)10Loh
PromoterTcra, T cell receptor alpha chain, mouse, laboratoryPromoterTcrb, T cell receptor beta chain, mouse, laboratoryExpressed GeneTcra, T cell receptor alpha chain, mouse, laboratoryExpressed GeneTcrb, T cell receptor beta chain, mouse, laboratory
Strain of Origin
(C57BL/6 x C3H)F1 x BALB/c
Chromosome
General Note
Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment.
Molecular Note
The transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells.
These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor.
Mutations Made By
Dr. Dennis Loh, Hoffman LaRoche
Disease Terms
This mouse can be used to support research in many areas including:
Immunology, Inflammation and Autoimmunity ResearchRearranged Antigen-Specific T Cell Receptor Transgenesclass II restrictedResearch ToolsImmunology, Inflammation and Autoimmunity ResearchT Cell Receptor Transgenics
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX& Mice strainGenotype: Tg(DO11.10)10Dlo/?immune system phenotypeabnormal thymus physiology20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes (MGI Ref ID )3 days after administration of peptide the cortical however, normal cellularity exists in the medulla (MGI Ref ID )apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas (MGI Ref ID )peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8 (MGI Ref ID )decreased CD4-positive, alpha beta T cell numberCD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide (MGI Ref ID )decreased double-positive T cell numberCD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide (MGI Ref ID )hematopoietic system phenotypeabnormal thymus physiology20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes (MGI Ref ID )3 days after administration of peptide the cortical however, normal cellularity exists in the medulla (MGI Ref ID )apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas (MGI Ref ID )peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8 (MGI Ref ID )decreased CD4-positive, alpha beta T cell numberCD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide (MGI Ref ID )decreased double-positive T cell numberCD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide (MGI Ref ID )endocrine/exocrine gland phenotypeabnormal thymus physiology20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes (MGI Ref ID )3 days after administration of peptide the cortical however, normal cellularity exists in the medulla (MGI Ref ID )apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas (MGI Ref ID )peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8 (MGI Ref ID )
References
Murphy KM; Heimberger AB; Loh DY. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250(-3.
Additional ReferencesChen W; Jin W; Tian H; Sicurello P; Frank M; Orenstein JM; Wahl SM. 2001. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med 194(4):439-53. Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11.
Additional - Tg(DO11.10)10Dlo relatedAbarrategui I; Krangel MS. 2007. Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J 26(20):4380-90. Abboud G; Staumont-Salle D; Kanda A; Roumier T; Deruytter N; Lavogiez C; Fleury S; Remy P; Papin JP; Capron M; Dombrowicz D. 2009. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol 182(10):6517-26. Abe BT; Shin DS; Mocholi E; Macian F. 2012. NFAT1 supports tumor-induced anergy of CD4(+) T cells. Cancer Res 72(18):4642-51. Abe Y; Kamachi F; Kawamoto T; Makino F; Ito J; Kojima Y; Moustapha Ael D; Usui Y; Yagita H; Takasaki Y; Okumura K; Akiba H. 2013. TIM-4 has dual function in the induction and effector phases of murine arthritis. J Immunol 191(9):4562-72. AbuAttieh M; Rebrovich M; Wettstein PJ; Vuk-Pavlovic Z; Limper AH; Platt JL; Cascalho M. 2007. Fitness of cell-mediated immunity independent of repertoire diversity. J Immunol 178(5):2950-60. Agata Y; Tamaki N; Sakamoto S; Ikawa T; Masuda K; Kawamoto H; Murre C. 2007. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity 27(6):871-84. Al-Shami A; Spolski R; Kelly J; Keane-Myers A; Leonard WJ. 2005. A role for TSLP in the development of inflammation in an asthma model. J Exp Med 202(6):829-39. Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. Alari-Pahissa E; Notario L; Lorente E; Vega-Ramos J; Justel A; Lopez D; Villadangos JA; Lauzurica P. 2012. CD69 does not affect the extent of T cell priming. PLoS One 7(10):e48593. Albacker LA; Karisola P; Chang YJ; Umetsu SE; Zhou M; Akbari O; Kobayashi N; Baumgarth N; Freeman GJ; Umetsu DT; Dekruyff RH. 2010. TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells. J Immunol 185(11):6839-49. Albrecht I; Niesner U; Janke M; Menning A; Loddenkemper C; Kuhl AA; Lepenies I; Lexberg MH; Westendorf K; Hradilkova K; Grun J; Hamann A; Epstein JA; Chang HD; Tokoyoda K; Radbruch A. 2010. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol 40(11):. Albrecht M; Arnhold M; Lingner S; Mahapatra S; Bruder D; Hansen G; Dittrich AM. 2012. IL-4 attenuates pulmonary epithelial cell-mediated suppression of T cell priming. PLoS One 7(9):e45916. Alegre ML; Shiels H; Thompson CB; Gajewski TF. 1998. Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol 161(7):3347-56. Aliahmad P; Kaye J. 2008. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med 205(1):245-56. Allenspach EJ; Cullinan P; Tong J; Tang Q; Tesciuba AG; Cannon JL; Takahashi SM; Morgan R; Burkhardt JK; Sperling AI. 2001. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15(5):739-50. Angela M; Endo Y; Asou HK; Yamamoto T; Tumes DJ; Tokuyama H; Yokote K; Nakayama T. 2016. Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARgamma directs early activation of T cells. Nat Commun 7:13683. Ansel KM; Greenwald RJ; Agarwal S; Bassing CH; Monticelli S; Interlandi J; Djuretic IM; Lee DU; Sharpe AH; Alt FW; Rao A. 2004. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol 5(12):1251-9. Aoki-Yoshida A; Yamada K; Hachimura S; Sashihara T; Ikegami S; Shimizu M; Totsuka M. 2016. Enhancement of Oral Tolerance Induction in DO11.10 Mice by Lactobacillus gasseri OLL2809 via Increase of Effector Regulatory T Cells. PLoS One 11(7):e0158643. Arredouani MS; Franco F; Imrich A; Fedulov A; Lu X; Perkins D; Soininen R; Tryggvason K; Shapiro SD; Kobzik L. 2007. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol 178(9):5912-20. Artis D; Kane CM; Fiore J; Zaph C; Shapira S; Joyce K; Macdonald A; Hunter C; Scott P; Pearce EJ. 2005. Dendritic cell-intrinsic expression of NF-kappaB1 is required to promote optimal Th2 cell differentiation. J Immunol 174(11):7154-9. Ashino S; Wakita D; Shiohama Y; Iwakura Y; Chamoto K; Ohkuri T; Kitamura H; Nishimura T. 2010. A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma} production in order to induce airway hyperresponsiveness. Int Immunol 22(6):503-13. Atochina O; Da'dara AA; Walker M; Harn DA. 2008. The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo. Immunology 125(1):111-21. Attridge K; Kenefeck R; Wardzinski L; Qureshi OS; Wang CJ; Manzotti C; Okkenhaug K; Walker LS. 2014. IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol 192(5):. Attridge K; Wang CJ; Wardzinski L; Kenefeck R; Chamberlain JL; Manzotti C; Kopf M; Walker LS. 2012. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood 119(20):4656-64. Au-Yeung BB; Katzman SD; Fowell DJ. 2006. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol 176(7):3895-9. Aubin E; Lemieux R; Bazin R. 2010. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood 115(9):1727-34. Aubin E; Proulx DP; Trepanier P; Lemieux R; Bazin R. 2011. Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83. Avci FY; Li X; Tsuji M; Kasper DL. 2011. A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12):1602-9. Azzam HS; DeJarnette JB; Huang K; Emmons R; Park CS; Sommers CL; El-Khoury D; Shores EW; Love PE. 2001. Fine tuning of TCR signaling by CD5. J Immunol 166(9):5464-72. Baba T; Badr Mel S; Tomaru U; Ishizu A; Mukaida N. 2012. Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpalpha+ dendritic cells: a murine model. PLoS One 7(7):e41154. Baba T; Nakamoto Y; Mukaida N. 2009. Crucial contribution of thymic Sirpalpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol 183(5):3053-63. Bakocevic N; Worbs T; Davalos-Misslitz A; Forster R. 2010. T cell-dendritic cell interaction dynamics during the induction of respiratory tolerance and immunity. J Immunol 184(3):1317-27. Balasubramani A; Shibata Y; Crawford GE; Baldwin AS; Hatton RD; Weaver CT. 2010. Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity 33(1):35-47. Baldeviano GC; Barin JG; Talor MV; Srinivasan S; Bedja D; Zheng D; Gabrielson K; Iwakura Y; Rose NR; Cihakova D. 2010. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 106(10):1646-55. Banczyk D; Kalies K; Nachbar L; Bergmann L; Schmidt P; Bode U; Teegen B; Steven P; Lange T; Textor J; Ludwig RJ; Stocker W; Konig P; Bell E; Westermann J. 2014. Activated CD4+ T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation. Eur J Immunol 44(1):93-102. Banerjee D; Liou HC; Sen R. 2005. c-Rel-dependent priming of naive T cells by inflammatory cytokines. Immunity 23(4):445-58. Banerjee H; Das A; Srivastava S; Mattoo HR; Thyagarajan K; Khalsa JK; Tanwar S; Das DS; Majumdar SS; George A; Bal V; Durdik JM; Rath S. 2012. A role for apoptosis-inducing factor in T cell development. J Exp Med 209(9):1641-53. Barin JG; Baldeviano GC; Talor MV; Wu L; Ong S; Quader F; Chen P; Zheng D; Caturegli P; Rose NR; Cihakova D. 2012. Macrophages participate in IL-17-mediated inflammation. Eur J Immunol 42(3):726-36. Barron L; Smith AM; El Kasmi KC; Qualls JE; Huang X; Cheever A; Borthwick LA; Wilson MS; Murray PJ; Wynn TA. 2013. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One 8(4):e61961. Bassiri H; Carding SR. 2001. A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. J Immunol 166(10):5945-54. Batten M; Ramamoorthi N; Kljavin NM; Ma CS; Cox JH; Dengler HS; Danilenko DM; Caplazi P; Wong M; Fulcher DA; Cook MC; King C; Tangye SG; de Sauvage FJ; Ghilardi N. 2010. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med 207(13):. Bell BD; Kitajima M; Larson RP; Stoklasek TA; Dang K; Sakamoto K; Wagner KU; Reizis B; Hennighausen L; Ziegler SF. 2013. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 14(4):364-71. Bemark M; Sale JE; Kim HJ; Berek C; Cosgrove RA; Neuberger MS. 2000. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity J Exp Med 192(10):1509-14. Bensinger SJ; Bradley MN; Joseph SB; Zelcer N; Janssen EM; Hausner MA; Shih R; Parks JS; Edwards PA; Jamieson BD; Tontonoz P. 2008. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134(1):97-111. Berenson LS; Gavrieli M; Farrar JD; Murphy TL; Murphy KM. 2006. Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol 177(8):. Berenson LS; Yang J; Sleckman BP; Murphy TL; Murphy KM. 2006. Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol 176(8):4616-21. Berner VK; duPre SA; Redelman D; Hunter KW. 2015. Microparticulate beta-glucan vaccine conjugates phagocytized by dendritic cells activate both naive CD4 and CD8 T cells in vitro. Cell Immunol 298(1-2):104-14. Bhatia S; Sun K; Almo SC; Nathenson SG; Hodes RJ. 2010. Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation. J Immunol 184(4):1821-8. Bhaumik S; Giffon T; Bolinger D; Kirkman R; Lewis DB; Weaver CT; Randolph DA. 2013. Retinoic Acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants. J Immunol 190(6):2603-13. Bihl F; Pecheur J; Breart B; Poupon G; Cazareth J; Julia V; Glaichenhaus N; Braud VM. 2010. Primed Antigen-Specific CD4+ T Cells Are Required for NK Cell Activation In Vivo upon Leishmania major Infection. J Immunol 185(4):2174-81. Blank F; Stumbles PA; Seydoux E; Holt PG; Fink A; Rothen-Rutishauser B; Strickland DH; von Garnier C. 2013. Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes. Am J Respir Cell Mol Biol 49(1):67-77. Blyszczuk P; Behnke S; Luscher TF; Eriksson U; Kania G. 2013. GM-CSF promotes inflammatory dendritic cell formation but does not contribute to disease progression in experimental autoimmune myocarditis. Biochim Biophys Acta 4-44. Bommireddy R; Babcock GF; Singh RR; Doetschman T. 2008. TGFbeta1 deficiency does not affect the generation and maintenance of CD4(+)CD25(+)FOXP3(+) putative T(reg) cells, but causes their numerical inadequacy and loss of regulatory function. Clin Immunol 127(2):206-13. Bonder CS; Clark SR; Norman MU; Johnson P; Kubes P. 2006. Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood 107(12):. Bos R; Sherman LA. 2010. CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res 70(21):8368-77. Boue J; Blanpied C; Brousset P; Vergnolle N; Dietrich G. 2011. Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice. J Immunol 186(9):5078-84. Bouguermouh S; Van VQ; Martel J; Gautier P; Rubio M; Sarfati M. 2008. CD47 expression on T cell is a self-control negative regulator of type 1 immune response. J Immunol 180(12):8073-82. Bourgeois C; Stockinger B. 2006. CD25+CD4+ regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia. J Immunol 177(7):4558-66. Brabb T; von Dassow P; Ordonez N; Schnabel B; Duke B; Goverman J. 2000. In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J Exp Med 192(6):871-80. Brahmakshatriya V; Kuang Y; Devarajan P; Xia J; Zhang W; Vong AM; Swain SL. 2017. IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo. J Immunol 198(7):. Brereton CF; Sutton CE; Ross PJ; Iwakura Y; Pizza M; Rappuoli R; Lavelle EC; Mills KH. 2011. Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production. J Immunol 186(10):. Broere F; du Pre MF; van Berkel LA; Garssen J; Schmidt-Weber CB; Lambrecht BN; Hendriks RW; Nieuwenhuis EE; Kraal G; Samsom JN. 2009. Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4. Mucosal Immunol 2(3):254-64. Brown DM; Dilzer AM; Meents DL; Swain SL. 2006. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 177(5):2888-98. Brown DM; Kamperschroer C; Dilzer AM; Roberts DM; Swain SL. 2009. IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. Cell Immunol 257(1-2):69-79. Bryce PJ; Oyoshi MK; Kawamoto S; Oettgen HC; Tsitsikov EN. 2006. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. Int Immunol 18(1):101-11. Buckley MW; Arandjelovic S; Trampont PC; Kim TS; Braciale TJ; Ravichandran KS. 2014. Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation. PLoS One 9(8):e105576. Byram SC; Carson MJ; DeBoy CA; Serpe CJ; Sanders VM; Jones KJ. 2004. CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation. J Neurosci 24(18):4333-9. Callen E; Faryabi RB; Luckey M; Hao B; Daniel JA; Yang W; Sun HW; Dressler G; Peng W; Chi H; Ge K; Krangel MS; Park JH; Nussenzweig A. 2012. The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. Immunity 37(6):971-85. Caminschi I; Ahmet F; Heger K; Brady J; Nutt SL; Vremec D; Pietersz S; Lahoud MH; Schofield L; Hansen DS; O'Keeffe M; Smyth MJ; Bedoui S; Davey GM; Villadangos JA; Heath WR; Shortman K. 2007. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med 204(11):2579-90. Cannon JL; Collins A; Mody PD; Balachandran D; Henriksen KJ; Smith CE; Tong J; Clay BS; Miller SD; Sperling AI. 2008. CD43 regulates Th2 differentiation and inflammation. J Immunol 180(11):7385-93. Cannon JL; Mody PD; Blaine KM; Chen EJ; Nelson AD; Sayles LJ; Moore TV; Clay BS; Dulin NO; Shilling RA; Burkhardt JK; Sperling AI. 2011. CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell 22(7):954-63. Carabelli J; Quattrocchi V; D'Antuono A; Zamorano P; Tribulatti MV; Campetella O. 2017. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation. J Leukoc Biol 102(5):. Carlsson F; Hjelm F; Conrad DH; Heyman B. 2007. IgE enhances specific antibody and T-cell responses in mice overexpressing CD23. Scand J Immunol 66(2-3):261-70. Carpenter AC; Yang-Iott KS; Chao LH; Nuskey B; Whitlow S; Alt FW; Bassing CH. 2009. Assembled DJbeta complexes influence TCRbeta chain selection and peripheral Vbeta repertoire. J Immunol 182(9):5586-95. Carter J; Vaitaitis GM; Waid DM; Wagner DH. 2012. CD40 engagement of CD4(+) CD40(+) T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance. Eur J Immunol 42(2):424-35. Carter JD; Calabrese GM; Naganuma M; Lorenz U. 2005. Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells. J Immunol 174(11):6627-38. Carter JD; Neel BG; Lorenz U. 1999. The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. Int Immunol 11(12):. Casati A; Zimmermann VS; Benigni F; Bertilaccio MT; Bellone M; Mondino A. 2005. The immunogenicity of dendritic cell-based vaccines is not hampered by Doxorubicin and melphalan administration. J Immunol 174(6):3317-25. Castro AG; Hauser TM; Cocks BG; Abrams J; Zurawski S; Churakova T; Zonin F; Robinson D; Tangye SG; Aversa G; Nichols KE; de Vries JE; Lanier LL; O'Garra A. 1999. Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells. J Immunol 163(11):5860-70. Chai JG; Tsang JY; Lechler R; Simpson E; Dyson J; Scott D. 2002. CD4+CD25+ T cells as immunoregulatory T cells in vitro. Eur J Immunol 32(8):2365-75. Chamoto K; Wakita D; Narita Y; Zhang Y; Noguchi D; Ohnishi H; Iguchi T; Sakai T; Ikeda H; Nishimura T. 2006. An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy. Cancer Res 66(3):1809-17. Chan CW; Crafton E; Fan HN; Flook J; Yoshimura K; Skarica M; Brockstedt D; Dubensky TW; Stins MF; Lanier LL; Pardoll DM; Housseau F. 2006. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med 12(2):207-13. Chang J; Voorhees TJ; Liu Y; Zhao Y; Chang CH. 2010. Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A. Proc Natl Acad Sci U S A 107(18):8340-5. Chang JH; Kim YJ; Han SH; Kang CY. 2009. IFN-gamma-STAT1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis. Eur J Immunol 39(5):1241-51. Chang SY; Cha HR; Uematsu S; Akira S; Igarashi O; Kiyono H; Kweon MN. 2008. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol 180(3):1609-18. Chang X; Zheng P; Liu Y. 2008. Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity. J Immunol 181(4):. Chen L; Arora M; Yarlagadda M; Oriss TB; Krishnamoorthy N; Ray A; Ray P. 2006. Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide. J Immunol 177(4):2373-83. Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. Chen Z; Han Y; Gu Y; Liu Y; Jiang Z; Zhang M; Cao X. 2013. CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway. J Immunol 190(12):6145-54. Chiba Y; Shida K; Nagata S; Wada M; Bian L; Wang C; Shimizu T; Yamashiro Y; Kiyoshima-Shibata J; Nanno M; Nomoto K. 2010. Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei. Immunology 130(3):352-62. Chikuma S; Abbas AK; Bluestone JA. 2005. B7-independent inhibition of T cells by CTLA-4. J Immunol 175(1):177-81. Chilton PM; Mitchell TC. 2006. CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen. Infect Immun 74(7):4180-9. Chitnis T; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2004. Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo. J Immunol 172(7):4260-5. Chu KH; Chiang BL. 2012. Regulatory T cells induced by mucosal B cells alleviate allergic airway hypersensitivity. Am J Respir Cell Mol Biol 46(5):651-9. Chung Y; Ko SY; Ko HJ; Kang CY. 2005. Split peripheral tolerance: CD40 ligation blocks tolerance induction for CD8 T cells but not for CD4 T cells in response to intestinal antigens. Eur J Immunol 35(5):1381-90. Clough LE; Wang CJ; Schmidt EM; Booth G; Hou TZ; Ryan GA; Walker LS. 2008. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J Immunol 180(8):. Cohn L; Herrick C; Niu N; Homer R; Bottomly K. 2001. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 166(4):2760-7. Collier SP; Collins PL; Williams CL; Boothby MR; Aune TM. 2012. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol 189(5):2084-8. Cong Y; Feng T; Fujihashi K; Schoeb TR; Elson CO. 2009. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A 106(46):19256-61. Coombes JL; Siddiqui KR; Arancibia-Carcamo CV; Hall J; Sun CM; Belkaid Y; Powrie F. 2007. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757-64. Corn RA; Aronica MA; Zhang F; Tong Y; Stanley SA; Kim SR; Stephenson L; Enerson B; McCarthy S; Mora A; Boothby M. 2003. T cell-intrinsic requirement for NF-kappaB induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response. J Immunol 171(4):1816-24. Corn RA; Hunter C; Liou HC; Siebenlist U; Boothby MR. 2005. Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J Immunol 175(4):2102-10. Cornwell MM. 1991. Molecular biology of P-glycoprotein. Cancer Treat Res 57:37-56. Cruise MW; Lukens JR; Nguyen AP; Lassen MG; Waggoner SN; Hahn YS. 2006. Fas ligand is responsible for CXCR3 chemokine induction in CD4+ T cell-dependent liver damage. J Immunol 176(10):6235-44. Curotto de Lafaille MA; Kutchukhidze N; Shen S; Ding Y; Yee H; Lafaille JJ. 2008. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 29(1):114-26. Curotto de Lafaille MA; Muriglan S; Sunshine MJ; Lei Y; Kutchukhidze N; Furtado GC; Wensky AK; Olivares-Villagomez D; Lafaille JJ. 2001. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med 194(9):1349-59. Curry JD; Geier JK; Schlissel MS. 2005. Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis. Nat Immunol 6(12):1272-9. Curtiss ML; Gorman JV; Businga TR; Traver G; Singh M; Meyerholz DK; Kline JN; Murphy AJ; Valenzuela DM; Colgan JD; Rothman PB; Cassel SL. 2012. Tim-1 regulates Th2 responses in an airway hypersensitivity model. Eur J Immunol 42(3):651-61. D'Orazio TJ; Mayhew E; Niederkorn JY. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1 J Immunol 166(1):26-32. Dardalhon V; Schubart AS; Reddy J; Meyers JH; Monney L; Sabatos CA; Ahuja R; Nguyen K; Freeman GJ; Greenfield EA; Sobel RA; Kuchroo VK. 2005. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol 175(3):1558-65. Das A; Ranganathan V; Umar D; Thukral S; George A; Rath S; Bal V. 2017. Effector/memory CD4 T cells making either Th1 or Th2 cytokines commonly co-express T-bet and GATA-3. PLoS One 12(10):e0185932. Davalos-Misslitz AC; Worbs T; Willenzon S; Bernhardt G; Forster R. 2007. Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood 110(13):4351-9. DeRyckere D; DeGregori J. 2005. E2F1 and E2F2 are differentially required for homeostasis-driven and antigen-induced T cell proliferation in vivo. J Immunol 175(2):647-55. Del Blanco B; Angulo U; Krangel MS; Hernandez-Munain C. 2015. T-cell receptor alpha enhancer is inactivated in alphabeta T lymphocytes. Proc Natl Acad Sci U S A 112(14):E1744-53. Delano MJ; Scumpia PO; Weinstein JS; Coco D; Nagaraj S; Kelly-Scumpia KM; O'Malley KA; Wynn JL; Antonenko S; Al-Quran SZ; Swan R; Chung CS; Atkinson MA; Ramphal R; Gabrilovich DI; Reeves WH; Ayala A; Phillips J; Laface D; Heyworth PG; Clare-Salzler M; Moldawer LL. 2007. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 204(6):1463-74. Deng J; Dekruyff RH; Freeman GJ; Umetsu DT; Levy S. 2002. Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses. Int Immunol 14(5):513-23. Deppong C; Degnan JM; Murphy TL; Murphy KM; Green JM. 2008. B and T lymphocyte attenuator regulates T cell survival in the lung. J Immunol 181(5):2973-9. Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. Ding Z; Bergman A; Rutemark C; Ouchida R; Ohno H; Wang JY; Heyman B. 2013. Complement-activating IgM enhances the humoral but not the T cell immune response in mice. PLoS One 8(11):e81299. Djuretic IM; Levanon D; Negreanu V; Groner Y; Rao A; Ansel KM. 2007. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8(2):145-53. Dluzniewska J; Zou L; Harmon IR; Ellingson MT; Peterson EJ. 2007. Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis. Eur J Immunol 37(11):3208-19. Doebis C; Siegmund K; Loddenkemper C; Lowe JB; Issekutz AC; Hamann A; Huehn J; Syrbe U. 2008. Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Am J Pathol 173(4):1067-76. Doetschman T; Sholl A; Chen HD; Gard C; Hildeman DA; Bommireddy R. 2011. Divergent effects of calcineurin Abeta on regulatory and conventional T-cell homeostasis. Clin Immunol 138(3):321-30. Doi T; Kanai T; Mikami Y; Sujino T; Jun L; Ono Y; Hayashi A; Hibi T. 2012. IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine. Biochem Biophys Res Commun 425(4):918-23. Dooms H; Wolslegel K; Lin P; Abbas AK. 2007. Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med 204(3):547-57. Dorsey NJ; Chapoval SP; Smith EP; Skupsky J; Scott DW; Keegan AD. 2013. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. J Immunol 191(4):1517-28. Douin-Echinard V; Laffont S; Seillet C; Delpy L; Krust A; Chambon P; Gourdy P; Arnal JF; Guery JC. 2008. Estrogen Receptor {alpha}, but Not {beta}, Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production. J Immunol 180(6):3661-9. Duarte J; Agua-Doce A; Oliveira VG; Fonseca JE; Graca L. 2010. Modulation of IL-17 and Foxp3 expression in the prevention of autoimmune arthritis in mice. PLoS One 5(5):e10558. Dunford PJ; O'Donnell N; Riley JP; Williams KN; Karlsson L; Thurmond RL. 2006. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J Immunol 176(11):7062-70. Dzialo-Hatton R; Milbrandt J; Hockett RD; Weaver CT. 2001. Differential expression of fas ligand in th1 and th2 cells is regulated by early growth response gene and nf-at family members. J Immunol 166(7):4534-42. Ebihara M; Hattori M; Yoshida T. 2007. Distinctly different sensitivity in the induction and reversal of anergy of Th1 and Th2 cells. Biosci Biotechnol Biochem 71(1):130-7. Eddahri F; Denanglaire S; Bureau F; Spolski R; Leonard WJ; Leo O; Andris F. 2009. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113(11):2426-33. Ekkens MJ; Liu Z; Liu Q; Whitmire J; Xiao S; Foster A; Pesce J; VanNoy J; Sharpe AH; Urban JF; Gause WC. 2003. The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. J Immunol 170(1):384-93. Elgueta R; Sepulveda FE; Vilches F; Vargas L; Mora JR; Bono MR; Rosemblatt M. 2008. Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells. J Immunol 180(10):6501-7. Elyaman W; Bassil R; Bradshaw EM; Orent W; Lahoud Y; Zhu B; Radtke F; Yagita H; Khoury SJ. 2012. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity 36(4):623-34. Endo Y; Hirahara K; Iinuma T; Shinoda K; Tumes DJ; Asou HK; Matsugae N; Obata-Ninomiya K; Yamamoto H; Motohashi S; Oboki K; Nakae S; Saito H; Okamoto Y; Nakayama T. 2015. The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42(2):294-308. Erazo A; Kutchukhidze N; Leung M; Christ AP; Urban JF Jr; Curotto de Lafaille MA; Lafaille JJ. 2007. Unique Maturation Program of the IgE Response In Vivo. Immunity 26(2):191-203. Fahlen L; Read S; Gorelik L; Hurst SD; Coffman RL; Flavell RA; Powrie F. 2005. T cells that cannot respond to TGF-{beta} escape control by CD4+CD25+ regulatory T cells. J Exp Med 201(5):737-46. Farazi M; Cohn Z; Nguyen J; Weinberg AD; Ruby CE. 2014. Early-onset age-related changes in dendritic cell subsets can impair antigen-specific T helper 1 (Th1) CD4 T cell priming. J Leukoc Biol 96(2):245-54. Fehervari Z; Sakaguchi S. 2004. Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells. Int Immunol 16(12):1769-80. Feuerer M; Eulenburg K; Loddenkemper C; Hamann A; Huehn J. 2006. Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176(5):2857-63. Foger N; Rangell L; Danilenko DM; Chan AC. 2006. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313(. Foulds KE; Rotte MJ; Paley MA; Singh B; Douek DC; Hill BJ; O'Shea JJ; Watford WT; Seder RA; Wu CY. 2008. IFN-gamma mediates the death of Th1 cells in a paracrine manner. J Immunol 180(2):842-9. Frick JS; Zahir N; Muller M; Kahl F; Bechtold O; Lutz MB; Kirschning CJ; Reimann J; Jilge B; Bohn E; Autenrieth IB. 2006. Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: an important role for IL-6. Eur J Immunol 36(6):1537-47. Friedman RS; Jacobelli J; Krummel MF. 2006. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol 7(10):1101-8. Fukaya T; Takagi H; Sato Y; Sato K; Eizumi K; Taya H; Shin T; Chen L; Dong C; Azuma M; Yagita H; Malissen B; Sato K. 2010. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood 116(13):2266-76. Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):. Gallo E; Katzman S; Villarino AV. 2012. IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens. Eur J Immunol 42(9):2322-8. Gandhapudi SK; Murapa P; Threlkeld ZD; Ward M; Sarge KD; Snow C; Woodward JG. 2013. Heat shock transcription factor 1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division during stress. J Immunol 191(8):4068-79. Gao Y; Herndon JM; Zhang H; Griffith TS; Ferguson TA. 1998. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J Exp Med 188(5):887-96. Gerth AJ; Lin L; Neurath MF; Glimcher LH; Peng SL. 2004. An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells. Gastroenterology 126(4):1115-21. Ghoreschi K; Bruck J; Kellerer C; Deng C; Peng H; Rothfuss O; Hussain RZ; Gocke AR; Respa A; Glocova I; Valtcheva N; Alexander E; Feil S; Feil R; Schulze-Osthoff K; Rupec RA; Lovett-Racke AE; Dringen R; Racke MK; Rocken M. 2011. Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208(11):. Girtsman T; Jaffar Z; Ferrini M; Shaw P; Roberts K. 2010. Natural Foxp3(+) regulatory T cells inhibit Th2 polarization but are biased toward suppression of Th17-driven lung inflammation. J Leukoc Biol 88(3):537-46. Glasmacher E; Hoefig KP; Vogel KU; Rath N; Du L; Wolf C; Kremmer E; Wang X; Heissmeyer V. 2010. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol 11(8):725-33. Godfrey DI; Kennedy J; Mombaerts P; Tonegawa S; Zlotnik A. 1994. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol 152(10):4783-92. Gokmen MR; Dong R; Kanhere A; Powell N; Perucha E; Jackson I; Howard JK; Hernandez-Fuentes M; Jenner RG; Lord GM. 2013. Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol 191(12):5925-32. Gollmer K; Asperti-Boursin F; Tanaka Y; Okkenhaug K; Vanhaesebroeck B; Peterson JR; Fukui Y; Donnadieu E; Stein JV. 2009. CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway. Blood 114(3):580-8. Gorman S; Judge MA; Burchell JT; Turner DJ; Hart PH. -dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses. Immunology 130(2):181-92. Graham DB; Bell MP; Huntoon CJ; Griffin MD; Tai X; Singer A; McKean DJ. 2006. CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling. J Immunol 177(9):. Gratz IK; Rosenblum MD; Maurano MM; Paw JS; Truong HA; Marshak-Rothstein A; Abbas AK. 2014. Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. J Immunol 192(4):1351-5. Gratz IK; Truong HA; Yang SH; Maurano MM; Lee K; Abbas AK; Rosenblum MD. 2013. Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues. J Immunol 190(9):4483-7. Greenwald RJ; Boussiotis VA; Lorsbach RB; Abbas AK; Sharpe AH. 2001. CTLA-4 regulates induction of anergy in vivo. Immunity 14(2):145-55. Grenningloh R; Kang BY; Ho IC. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med 201(4):615-26. Guiducci C; Valzasina B; Dislich H; Colombo MP. 2005. CD40/CD40L interaction regulates CD4(+)CD25(+) T reg homeostasis through dendritic cell-produced IL-2. Eur J Immunol 35(2):557-67. Guimont-Desrochers F; Beauchamp C; Chabot-Roy G; Dugas V; Hillhouse EE; Dusseault J; Langlois G; Gautier-Ethier P; Darwiche J; Sarfati M; Lesage S. 2009. Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes. Int Immunol 21(2):167-77. Haas JD; Nistala K; Petermann F; Saran N; Chennupati V; Schmitz S; Korn T; Wedderburn LR; Forster R; Krueger A; Prinz I. 2011. Expression of miRNAs miR-133b and miR-206 in the Il17a/f Locus Is Co-Regulated with IL-17 Production in alphabeta and gammadelta T Cells. PLoS One 6(5):e20171. Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. Hagen KA; Moses CT; Drasler EF; Podetz-Pedersen KM; Jameson SC; Khoruts A. 2004. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J Immunol 173(6):3909-15. Haile ST; Dalal SP; Clements V; Tamada K; Ostrand-Rosenberg S. 2013. Soluble CD80 restores T cell activation and overcomes tumor cell programmed death ligand 1-mediated immune suppression. J Immunol 191(5):2829-36. Hamano R; Baba T; Sasaki S; Tomaru U; Ishizu A; Kawano M; Yamagishi M; Mukaida N. 2014. Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses. Eur J Immunol 44(4):1005-15. Hammad H; Plantinga M; Deswarte K; Pouliot P; Willart MA; Kool M; Muskens F; Lambrecht BN. 2010. Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 207(10):. Hanlon A; Jang S; Salgame P. 2005. Cbl-b differentially regulates activation-induced apoptosis in T helper 1 and T helper 2 cells. Immunology 116(4):507-12. Hara H; Bakal C; Wada T; Bouchard D; Rottapel R; Saito T; Penninger JM. 2004. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med 200(9):1167-77. Hardtke S; Ohl L; Forster R. 2005. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106(6):1924-31. Haribhai D; Lin W; Relland LM; Truong N; Williams CB; Chatila TA. 2007. Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol 178(5):2961-72. Haribhai D; Williams JB; Jia S; Nickerson D; Schmitt EG; Edwards B; Ziegelbauer J; Yassai M; Li SH; Relland LM; Wise PM; Chen A; Zheng YQ; Simpson PM; Gorski J; Salzman NH; Hessner MJ; Chatila TA; Williams CB. 2011. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 35(1):109-22. Hartwig C; Mazzega M; Constabel H; Krishnaswamy JK; Gessner JE; Braun A; Tschernig T; Behrens GM. 2010. Fcgamma receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation. Eur J Immunol 40(5):1284-95. Hartwig C; Munder A; Glage S; Wedekind D; Schenk H; Seifert R; Neumann D. 2015. The histamine H4 -receptor (H4 R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice. Eur J Immunol 45(4):1129-40. Hathcock KS; Bowen S; Livak F; Hodes RJ. 2013. ATM influences the efficiency of TCRbeta rearrangement, subsequent TCRbeta-dependent T cell development, and generation of the pre-selection TCRbeta CDR3 repertoire. PLoS One 8(4):e62188. Hawlisch H; Belkaid Y; Baelder R; Hildeman D; Gerard C; Kohl J. 2005. C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity 22(4):415-26. Hawwari A; Krangel MS. 2007. Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci U S A 104(3):903-7. Hayashi N; Yoshimoto T; Izuhara K; Matsui K; Tanaka T; Nakanishi K. 2007. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-{gamma} and IL-13 production. Proc Natl Acad Sci U S A 104(37):14765-70. Hayashi RJ; Kanagawa O. 2006. Requirement of high-affinity IL-2-IL-2R interaction for T cell anergy induction. Int Immunol 18(5):645-51. He JS; Meyer-Hermann M; Xiangying D; Zuan LY; Jones LA; Ramakrishna L; de Vries VC; Dolpady J; Aina H; Joseph S; Narayanan S; Subramaniam S; Puthia M; Wong G; Xiong H; Poidinger M; Urban JF; Lafaille JJ; Curotto de Lafaille MA. 2013. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J Exp Med 210(12):2755-71. Heckman KL; Radhakrishnan S; Peikert T; Iijima K; McGregor HC; Bell MP; Kita H; Pease LR. 2008. T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation. Eur J Immunol 38(9):2464-74. Herkel J; Jagemann B; Wiegard C; Lazaro JF; Lueth S; Kanzler S; Blessing M; Schmitt E; Lohse AW. 2003. MHC class II-expressing hepatocytes function as antigen-presenting cells and activate specific CD4 T lymphocyutes. Hepatology 37(5):1079-85. Hermiston ML; Zikherman J; Tan AL; Lam VC; Cresalia NM; Oksenberg N; Goren N; Brassat D; Oksenberg JR; Weiss A. 2009. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A 106(2):546-51. Herold KC; Lu J; Rulifson I; Vezys V; Taub D; Grusby MJ; Bluestone JA. 1997. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 159(9):4150-3. Hinterberger M; Aichinger M; da Costa OP; Voehringer D; Hoffmann R; Klein L. 2010. Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat Immunol 11(6):512-9. Hjelm F; Carlsson F; Verbeek S; Heyman B. 2005. IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice. Scand J Immunol 62(5):453-61. Hjelm F; Karlsson MC; Heyman B. 2008. A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen. J Immunol 180(10):6604-10. Hoeman CM; Dhakal M; Zaghouani AA; Cascio JA; Wan X; Khairallah MT; Chen W; Zaghouani H. 2013. Developmental expression of IL-12Rbeta2 on murine naive neonatal T cells counters the upregulation of IL-13Ralpha1 on primary Th1 cells and balances immunity in the newborn. J Immunol 190(12):6155-63. Hoshino A; Tsuji T; Matsuzaki J; Jinushi T; Ashino S; Teramura T; Chamoto K; Tanaka Y; Asakura Y; Sakurai T; Mita Y; Takaoka A; Nakaike S; Takeshima T; Ikeda H; Nishimura T. 2004. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 16(10):. Hosokawa H; Kimura MY; Shinnakasu R; Suzuki A; Miki T; Koseki H; van Lohuizen M; Yamashita M; Nakayama T. 2006. Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol 177(11):7656-64. Hosokawa H; Tanaka T; Endo Y; Kato M; Shinoda K; Suzuki A; Motohashi S; Matsumoto M; Nakayama KI; Nakayama T. 2016. Akt1-mediated Gata3 phosphorylation controls the repression of IFNgamma in memory-type Th2 cells. Nat Commun 7:11289. Hosokawa H; Tanaka T; Kato M; Shinoda K; Tohyama H; Hanazawa A; Tamaki Y; Hirahara K; Yagi R; Sakikawa I; Morita A; Nagira M; Poyurovsky MV; Suzuki Y; Motohashi S; Nakayama T. 2013. Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc Natl Acad Sci U S A 110(46):18626-31. Howland KC; Ausubel LJ; London CA; Abbas AK. 2000. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J Immunol 164(9):4465-70. Hsieh CS; Macatonia SE; O'Garra A; Murphy KM. 1995. T cell genetic background determines default T helper phenotype development in vitro. J Exp Med 181(2):713-21. Hsu LY; Tan YX; Xiao Z; Malissen M; Weiss A. 2009. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med 206(11):2527-41. Hu J; Qi Q; August A. 2010. Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells. PLoS One 5(1):e8891. Huang CY; Lin YC; Hsiao WY; Liao FH; Huang PY; Tan TH. 2012. DUSP4 deficiency enhances CD25 expression and CD4(+) T-cell proliferation without impeding T-cell development. Eur J Immunol 42(2):476-88. Huang JH; Cardenas-Navia LI; Caldwell CC; Plumb TJ; Radu CG; Rocha PN; Wilder T; Bromberg JS; Cronstein BN; Sitkovsky M; Dewhirst MW; Dustin ML. 2007. Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol 178(12):7747-55. Huang X; Zhu J; Yang Y. 2005. Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta. J Immunol 175(7):4283-91. Hurst SD; Sitterding SM; Ji S; Barrett TA. 1997. Functional differentiation of T cells in the intestine of T cell receptor transgenic mice. Proc Natl Acad Sci U S A 94(8):3920-5. Hwang ES; White IA; Ho IC. 2002. An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines. Proc Natl Acad Sci U S A 99(20):13026-30. Ichii H; Sakamoto A; Arima M; Hatano M; Kuroda Y; Tokuhisa T. 2007. Bcl6 is essential for the generation of long-term memory CD4+ T cells. Int Immunol 19(4):427-33. Iliev ID; Mileti E; Matteoli G; Chieppa M; Rescigno M. 2009. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol 2(4):340-50. Inoue J; Kanefuji T; Okazuka K; Watanabe H; Mishima Y; Kominami R. 2006. Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- mice. J Immunol 176(10):5871-9. Intlekofer AM; Takemoto N; Kao C; Banerjee A; Schambach F; Northrop JK; Shen H; Wherry EJ; Reiner SL. 2007. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med 204(9):2015-21. Intlekofer AM; Takemoto N; Wherry EJ; Longworth SA; Northrup JT; Palanivel VR; Mullen AC; Gasink CR; Kaech SM; Miller JD; Gapin L; Ryan K; Russ AP; Lindsten T; Orange JS; Goldrath AW; Ahmed R; Reiner SL. 2005. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol 6(12):1236-44. Ise W; Kohyama M; Nutsch KM; Lee HM; Suri A; Unanue ER; Murphy TL; Murphy KM. 2010. CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat Immunol 11(2):129-35. Ishigame H; Kakuta S; Nagai T; Kadoki M; Nambu A; Komiyama Y; Fujikado N; Tanahashi Y; Akitsu A; Kotaki H; Sudo K; Nakae S; Sasakawa C; Iwakura Y. 2009. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30(1):108-19. Ishiwata K; Watanabe N; Guo M; Tomihara K; Brumlik MJ; Yagita H; Pardoll D; Chen L; Shin T. 2010. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. J Immunol 184(4):2086-94. Ito T; Schaller M; Hogaboam CM; Standiford TJ; Sandor M; Lukacs NW; Chensue SW; Kunkel SL. 2009. TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest 119(1):33-46. Iwai H; Abe M; Hirose S; Tsushima F; Tezuka K; Akiba H; Yagita H; Okumura K; Kohsaka H; Miyasaka N; Azuma M. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171(6):2848-54. Iwamura C; Kimura MY; Shinoda K; Endo Y; Hasegawa A; Yamashita M; Nakayama T. 2007. Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int Immunol 19(6):755-62. Iwamura C; Shinoda K; Endo Y; Watanabe Y; Tumes DJ; Motohashi S; Kawahara K; Kinjo Y; Nakayama T. 2012. Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc Natl Acad Sci U S A 109(42):16992-7. Iwata A; Kawashima S; Kobayashi M; Okubo A; Kawashima H; Suto A; Hirose K; Nakayama T; Nakajima H. 2014. Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol 26(2):103-14. Iype T; Sankarshanan M; Mauldin IS; Mullins DW; Lorenz U. 2010. The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells. J Immunol 185(10):6115-27. Jacobsen J; Haabeth OA; Tveita AA; Schjetne KW; Munthe LA; Bogen B. 2014. Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells. J Immunol 192(9):4174-83. Jaffar Z; Ferrini ME; Shaw PK; FitzGerald GA; Roberts K. 2011. Prostaglandin Ipromotes the development of IL-17-producing gammadelta T cells that associate with the epithelium during allergic lung inflammation. J Immunol 187(10):5380-91. Jang IK; Zhang J; Chiang YJ; Kole HK; Cronshaw DG; Zou Y; Gu H. 2010. Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci U S A 107(23):10620-5. Jang MH; Sougawa N; Tanaka T; Hirata T; Hiroi T; Tohya K; Guo Z; Umemoto E; Ebisuno Y; Yang BG; Seoh JY; Lipp M; Kiyono H; Miyasaka M. 2006. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 176(2):803-10. Jang S; Morris S; Lukacs NW. 2013. TSLP promotes induction of Th2 differentiation but is not necessary during established allergen-induced pulmonary disease. PLoS One 8(2):e56433. Jang S; Uematsu S; Akira S; Salgame P. 2004. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol 173(5):3392-7. Jaume M; Laffont S; Chapey E; Blanpied C; Dietrich G. 2007. Opioid receptor blockade increases the number of lymphocytes without altering T cell response in draining lymph nodes in vivo. J Neuroimmunol 188(1-2):95-102. Jenner RG; Townsend MJ; Jackson I; Sun K; Bouwman RD; Young RA; Glimcher LH; Lord GM. 2009. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A 106(42):17876-81. Jiao L; Gao X; Joyee AG; Zhao L; Qiu H; Yang M; Fan Y; Wang S; Yang X. 2011. NK cells promote type 1 T cell immunity through modulating the function of dendritic cells during intracellular bacterial infection. J Immunol 187(1):401-11. Jin H; Oyoshi MK; Le Y; Bianchi T; Koduru S; Mathias CB; Kumar L; Le Bras S; Young D; Collins M; Grusby MJ; Wenzel J; Bieber T; Boes M; Silberstein LE; Oettgen HC; Geha RS. 2009. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest 119(1):47-60. Johansson M; Lycke N. 2003. A Unique Population of Extrathymically Derived alphabetaTCR(+)CD4(-)CD8(-) T Cells with Regulatory Functions Dominates the Mouse Female Genital Tract. J Immunol 170(4):1659-66. Jung YW; Schoeb TR; Weaver CT; Chaplin DD. 2006. Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168(5):1425-34. Kagami S; Nakajima H; Suto A; Hirose K; Suzuki K; Morita S; Kato I; Saito Y; Kitamura T; Iwamoto I. 2001. Stat5a regulates T helper cell differentiation by several distinct mechanisms. Blood 97(8):2358-65. Kaisho T; Takeuchi O; Kawai T; Hoshino K; Akira S. 2001. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 166(9):5688-94. Kallal LE; Schaller MA; Lindell DM; Lira SA; Lukacs NW. 2010. CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC. Eur J Immunol 40(4):1042-52. Kandula S; Abraham C. 2004. LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo. J Immunol 173(7):4443-51. Kang J; Huddleston SJ; Fraser JM; Khoruts A. 2008. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J Leukoc Biol 83(5):1230-9. Kania G; Siegert S; Behnke S; Prados-Rosales R; Casadevall A; Luscher TF; Luther SA; Kopf M; Eriksson U; Blyszczuk P. 2013. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23):2285-94. Kaplan MH; Wurster AL; Smiley ST; Grusby MJ. 1999. Stat6-dependent and -independent pathways for IL-4 production. J Immunol 163(12):6536-40. Kasagi S; Zhang P; Che L; Abbatiello B; Maruyama T; Nakatsukasa H; Zanvit P; Jin W; Konkel JE; Chen W. 2014. In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response. Sci Transl Med 6(241):241ra78. Kashiwakuma D; Suto A; Hiramatsu Y; Ikeda K; Takatori H; Suzuki K; Kagami S; Hirose K; Watanabe N; Iwamoto I; Nakajima H. 2010. B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses. J Immunol 185(5):2730-6. Kassner N; Krueger M; Yagita H; Dzionek A; Hutloff A; Kroczek R; Scheffold A; Rutz S. 2010. Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol 184(2):550-4. Katoh S; Kaminuma O; Hiroi T; Mori A; Ohtomo T; Maeda S; Shimizu H; Obase Y; Oka M. 2011. CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice. Eur J Immunol 41(11):. Katzman SD; Gallo E; Hoyer KK; Abbas AK. 2011. Differential requirements for Th1 and Th17 responses to a systemic self-antigen. J Immunol 186(8):4668-73. Kawakami T; Lichtnekert J; Thompson LJ; Karna P; Bouabe H; Hohl TM; Heinecke JW; Ziegler SF; Nelson PJ; Duffield JS. 2013. Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. J Immunol 191(6):3358-72. Kawashima S; Hirose K; Iwata A; Takahashi K; Ohkubo A; Tamachi T; Ikeda K; Kagami S; Nakajima H. 2012. beta-Glucan Curdlan Induces IL-10-Producing CD4+ T Cells and Inhibits Allergic Airway Inflammation. J Immunol 189(12):5713-21. Keino H; Takeuchi M; Kezuka T; Hattori T; Usui M; Taguchi O; Streilein JW; Stein-Streilein J. 2006. Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells. Invest Ophthalmol Vis Sci 47(3):1047-55. Keir ME; Liang SC; Guleria I; Latchman YE; Qipo A; Albacker LA; Koulmanda M; Freeman GJ; Sayegh MH; Sharpe AH. 2006. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 203(4):883-95. Kel JM; de Geus ED; van Stipdonk MJ; Drijfhout JW; Koning F; Nagelkerken L. 2008. Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation. Int Immunol 20(1):117-27. Kelly EM. 1974. Allelism of cloud-gray with steel. Mouse News Lett 50:21. Kenefeck R; Wang CJ; Kapadi T; Wardzinski L; Attridge K; Clough LE; Heuts F; Kogimtzis A; Patel S; Rosenthal M; Ono M; Sansom DM; Narendran P; Walker LS. 2015. Follicular helper T cell signature in type 1 diabetes. J Clin Invest 125(1):292-303. Kerfoot SM; Norman MU; Lapointe BM; Bonder CS; Zbytnuik L; Kubes P. 2006. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol 176(10):6225-34. Khare A; Krishnamoorthy N; Oriss TB; Fei M; Ray P; Ray A. 2013. Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance. J Immunol 191(1):25-9. Kim HJ; Hwang SJ; Kim BK; Jung KC; Chung DH. 2006. NKT cells play critical roles in the induction of oral tolerance by inducing regulatory T cells producing IL-10 and transforming growth factor beta, and by clonally deleting antigen-specific T cells. Immunology 118(1):101-11. Kim HR; Jeon BH; Lee HS; Im SH; Araki M; Araki K; Yamamura K; Choi SC; Park DS; Jun CD. 2011. IGSF4 is a novel TCR zeta-chain-interacting protein that enhances TCR-mediated signaling. J Exp Med 208(12):2545-60. Kimura MY; Hosokawa H; Yamashita M; Hasegawa A; Iwamura C; Watarai H; Taniguchi M; Takagi T; Ishii S; Nakayama T. 2005. Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J Exp Med 201(3):397-408. Kimura MY; Iwamura C; Suzuki A; Miki T; Hasegawa A; Sugaya K; Yamashita M; Ishii S; Nakayama T. 2007. Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J Immunol 178(8):4926-36. Kimzey SL; Liu P; Green JM. 2004. Requirement for CD28 in the effector phase of allergic airway inflammation. J Immunol 173(1):632-40. King SB; Knorn AM; Ohnmacht C; Voehringer D. 2008. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6. J Immunol 180(2):754-63. Kishimoto H; Surh CD; Sprent J. 1998. A role for Fas in negative selection of thymocytes in vivo. J Exp Med 187(9):1427-38. Kitajima M; Ito T; Tumes DJ; Endo Y; Onodera A; Hashimoto K; Motohashi S; Yamashita M; Nishimura T; Ziegler SF; Nakayama T. 2011. Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells. Cancer Res 71(14):4790-8. Kitajima M; Iwamura C; Miki-Hosokawa T; Shinoda K; Endo Y; Watanabe Y; Shinnakasu R; Hosokawa H; Hashimoto K; Motohashi S; Koseki H; Ohara O; Yamashita M; Nakayama T. 2009. Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J Immunol 183(8):5388-96. Kitajima M; Ziegler SF. 2013. Cutting edge: identification of the thymic stromal lymphopoietin-responsive dendritic cell subset critical for initiation of type 2 contact hypersensitivity. J Immunol 191(10):4903-7. Kitamei H; Iwabuchi K; Namba K; Yoshida K; Yanagawa Y; Kitaichi N; Kitamura M; Ohno S; Onoe K. 2006. Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate. J Leukoc Biol 79(6):. Knoechel B; Lohr J; Kahn E; Bluestone JA; Abbas AK. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202(10):1375-86. Knott PG; Gater PR; Dunford PJ; Fuentes ME; Bertrand CP. 2001. Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. J Immunol 166(2):1233-40. Kobayashi M; Ashino S; Shiohama Y; Wakita D; Kitamura H; Nishimura T. 2012. IFN-gamma elevates airway hyper-responsiveness via up-regulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model. Eur J Immunol 42(2):393-402. Kochetkova I; Golden S; Holderness K; Callis G; Pascual DW. 2010. IL-35 stimulation of CD39+ regulatory T cells confers pr}